There is limited knowledge about cancer patients' experiences of uncertainty while waiting for genome sequencing results, and whether prolonged uncertainty contributes to psychological factors in this context. To investigate uncertainty in patients with a cancer of likely hereditary origin while waiting for genome sequencing results, we collected questionnaire and interview data at baseline, and at three and 12 months follow up. Participants had negative attitudes towards uncertainty at baseline, and low levels of uncertainty at three and 12 months. Uncertainty about (...) genome sequencing did not change significantly over time [t = 0.660, p = 0.510]. Greater perceived susceptibility for cancer [r = 0.14, p < 0.01], fear of cancer recurrence [r = 0.19, p < 0.01], perceived importance of genome sequencing [r = 0.24, p < 0.01], intention to change behavior if a gene variant indicating risk is found [r = 0.29, p < 0.01], perceived ability to cope with results [r = 0.36, p < 0.01], and satisfaction with decision to have genome sequencing [r = 0.52, p < 0.01] were significantly correlated with negative attitudes towards uncertainty at baseline. Multiple primary cancer diagnoses [B = −2.364 [−4.238, −0.491], p = 0.014], lower perceived ability to cope with results [B = −0.1.881 [−3.403, −0.359], p = 0.016] at baseline, greater anxiety about genome sequencing [B = 0.347 [0.148, 0.546], p = 0.0012] at 3 months, and greater perceived uncertainty about genome sequencing [B = 0.494 [0.267, 0.721] p = 0.000] at 3 months significantly predicted greater perceived uncertainty about genome sequencing at 12 months. Greater perceived uncertainty about genome sequencing at 3 months significantly predicted greater anxiety about genome sequencing at 12 months [B = 0.291 [0.072, 0.509], p = 0.009]. Semi-structured interviews revealed that while participants were motivated to pursue genome sequencing as a strategy to reduce their illness and risk uncertainty, genome sequencing generated additional practical, scientific and personal uncertainties. Some uncertainties were consistently discussed over the 12 months, while others emerged over time. Similarly, some uncertainty coping strategies were consistent over time, while others emerged while patients waited for their genome sequencing results. This study demonstrates the complexity of uncertainty generated by genome sequencing for cancer patients and provides further support for the inter-relationship between uncertainty and anxiety. Helping patients manage their uncertainty may ameliorate psychological morbidity. (shrink)

Most debate about the ethical implications of modern biotechnology has centred around medical issues, but public concerns over the impact of agricultural biotechnologies have gathered momentum. This volume, resulting from the 55th University of Nottingham Easter School in Agricultural and Food Science, provides a survey of this new field of enquiry. The book will be of interest to a wide readership, including applied philosophers, sociologists, economists and ecologists, as well as biotechnologists and agricultural and food scientists.

Marx was barely 25 when he produced this astonishing rich body of work-including economic and Philosophical Manuscripts and On the Jewish Question.

This collection of essays addresses some of the central issues in modern social and political thought, such as: the revival of Marxism and its relevance to the social sciences; the analysis of social and political structures and social movements; and the future of advanced capitalist societies.

Drawing on the philosophies of Aristotle and Aquinas, the author is concerned with justifying the need and use of political authority in any well-ordered and good society. Authority is necessary, he argues, because individual virtue, no matter how enlightened, cannot alone bring about "the common good in matter." The leaders, the wise men, can help assure this common good, "the communication of excellence," throughout the social hierarchy by using their authority properly. The author does not deal with such questions as (...) to how the wise men are selected, how to guarantee that they will remaining wise, and who and what protects civil liberties and minority rights.--J. T. B. T. (shrink)

The comic is one of the principal esthetic categories; it unites the multifaceted experience of the social mind as it assimilates and cognizes the world, particularly the social world, on the basis of axioms of common sense, or even of public opinion about these axioms. Boldly violating the laws of logic and the verisimilitude of images, of normal connections and notions, and playing upon these violations, the comic nonetheless remains firmly on the side of common sense. The comic is inexhaustible (...) in its nuances — from light merriment and entertainment to malicious ridicule and satire, from gross farce to subtle forms of irony and humor. (shrink)

In The Theatre of Dionysus in Athens Dr. Pickard-Cambridge includes a most useful and convenient collection of south Italian vase-paintings which have been held to throw light on the stage-settings of Greek tragedy. He concludes that they give no evidence for Athens in the fifth century and in particular do not justify the assumption that interior scenes were played in a porch in front of the central door. The second conclusion is true, but some of the vases do show that (...) the central doors could be thrown wide open to display an interior scene. The first conclusion is formally correct, but it should be remembered that the “plays came from Athens, and it is at least possible that the south Italian producers modelled themselves on Athenian producers. In any case these vases are worthy of further consideration. (shrink)

This work is a departure from traditional investigations of induction. Rather than consider issues related to the justification or construction of a scientific inductive logic, Professor Will exposes, evaluates, and rejects the epistemological framework within which work in the philosophy of induction is usually conducted. He argues that the frustrating difficulties faced in the philosophy of induction are endemic to that theory of knowledge which "resulted from the empiricist criticism and revision of the basic Cartesian view that knowledge is a (...) kind of vision or intuition, that there are certain first intuitions, and that further knowledge consists of consequent intuitions elicited from or founded upon these." According to this view of knowledge, a knowledge claim can be justified in the face of the challenge of philosophical skepticism only if it is either itself indubitable or rests on some foundation that is indubitable. The burden of Will’s work is to show that this foundation or "justification" picture of knowledge is seriously mistaken and must be replaced with a more adequate and more realistic view. Human knowledge, he stresses, is best seen as analogous to a constitution. As human knowledge differs from area to area these constitutions differ, "just as history differs from horticulture and architecture from aviation." However, "collectively they form a huge sprawling entity that represents what may be thought of as the constitution for the institutionalized activity of human knowledge.". (shrink)

My chief object in these notes is to provide evidence for tracing the ancestry of certain themes, situations, and characters which appear in New Comedy; I hope, however, that they may also be useful for the study of Middle Comedy itself. I am therefore chiefly concerned with the period from 400 b.c. to 320 b.c., when Menander had begun to write; I have, however, given some dates after 320 which were necessary to complete my story, but I have left out (...) many plays by poets of New Comedy which can be dated in the decade 320–310 b.c. I have also omitted the originals of Plautus Amphitruo, Persa, and Menaechmi, although I am convinced that they all belong to Middle Comedy and hope to consider the problem more fully elsewhere; the tactics of the battle in the Amphitruo are possible for Epameinondas and Philip as well as for Alexander, but the clash of two kings seems to limit the reference to Alexander and Dareios as depicted in the famous mosaic, and the limits are 330–320 ; the original of the Persa must have been written before Alexander's conquests and the limits seem to be 345–338; Hueffher's late dating of the original of the Menaechmi has been successfully countered by Fraenkel and the whole feel of the play suggests Middle rather than New Comedy. The following list is arranged in decades, except where it has proved necessary to use a longer period. I have tabulated first the plays or victories dated by inscriptional or other firm evidence; among these I have included the plays dated by Geissler, without comment except where I disagree with him. (shrink)

Thomas Bertram Lonsdale Webster. the Persians decided on the best form of government in 520 B.C., but it is far more likely that the discussion reflects political theorising at Athens where he was writing during the contest for power between ...

Greek art and literature follow parallel courses through the long period from Homer to Euripides. Homer and Euripides, Dipylon vases and the latest white lekythoi are as far apart from each other as it is possible for works in the same medium to be. The distance can only be explained by a similar change in the views of artists, writers, and their public.